S-adenosylmethionine (SAMe) is essential for nearly all methylation reactions. It is the predominant methyl group donor in the methylation cycle. Methylation and histamine have a direct correlation, where histamine is deactivated by methyl compounds from SAMe. With high histamine levels, the body may become depleted in the methyl groups causing undermethylation.  Low SAMe is generally seen in these patients, due to the lack of methyl groups to deactivate the high histamine levels. Additionally, through SAMe’s action as a methyl donor, its action increases the activity of pathways which increases serotonin and dopamine levels, thereby assisting with mood elevation.

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